A research team proved samul-tang or Four substance Decoction treated on aged female’s infertility.

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By Namwook Cho, L.Ac.

Korea Institute of Oriental Medicine recently announced that samul-tang, a formula used to treat age-related conditions such as infertility and menstrual irregularities, increases the oocyte yield in aged females.

In the research, the team used 8 weeks old and 40 weeks old mice, administered distilled water to one group and gave samul-tang to the other group for 4 weeks. The mice group supplied with the herbal formula prevented age-related ovarian follicle loss. And the quality of oocytes and blastocysts were enhanced in samul-tang administrated mice compared to those of non-treated old mice.

Jihyung Kim, one of the authors, explained, “samul-tang triggered changes in aging-related genes linked to RAS-mediated pathway. Thus, we demonstrated samul-tang could be used to increase the oocyte yield in aged women.”

The research was recently published in “Aging.”

A Study Showed that Samul-tang Could Increase Chances Fertility In Age-Women

The formula prevents follicles loss and improved implantation potential

Korea Institute of Oriental Medicine recently announced that samul-tang, a formula used to treat age-related conditions such as infertility and menstrual irregularities, increases the oocyte yield in aged females.

In the research, the team used 8 weeks old and 40 weeks old mice, administered distilled water to one group and gave samul-tang to the other group for 4 weeks. The mice group supplied with the herbal formula prevented age-related ovarian follicle loss. And the quality of oocytes and blastocysts were enhanced in samul-tang administrated mice compared to those of non-treated old mice.

Especially, women who are more than 35 years old with poor ovarian responses have a declining oocyte yield in in vitro fertilization, high-dose follicle-stimulating hormone protocols are unsuccessful.

The research team tried to find an alternative to the traditional herbal formula, samul-tang. The formula is well-known mixed herbal medicine comprising equal proportions of Paeonia lactifloraLiqusticum striatumRehmannia glutinosa, and Angelica gigas. Pharmacological effects of the formula include anti-inflammatory, antioxidative, anti-stress, and anti-cancer effects. But mostly, the formula is prescribed to women with gynecological disorders such as irregular menstruation and postmenopausal syndrome.

 

 

 

 

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